General Information

  • ID:  hor002529
  • Uniprot ID:  NA
  • Protein name:  ORG 2766
  • Gene name:  NA
  • Organism:  Rattus norvegicus
  • Family:  NA
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  MEHFKF
  • Length:  6
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T1 Methionine oxidation
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Has trophic effects on neuronal tissue and when given postnatally, it can induce long-lasting changes in brain development.
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002529_AF2.pdbhor002529_ESM.pdb

Physical Information

Mass: 92735 Formula: C40H55N9O9S
Absent amino acids: ACDGILNPQRSTVWY Common amino acids: F
pI: 7.55 Basic residues: 2
Polar residues: 0 Hydrophobic residues: 2
Hydrophobicity: -51.67 Boman Index: -871
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 0
Instability Index: -4656.67 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  11033312
  • Title:  Postnatal Treatment With ACTH-(4-9) Analog ORG 2766 Attenuates N-methyl-D-aspartate-induced Excitotoxicity in Rat Nucleus Basalis in Adulthood